Synthesis of enantiopure chloroalcohols by enzymatic kinetic resolution.
نویسندگان
چکیده
3-Alkenyl and heteroaryl chloroalcohols have been obtained in excellent enantiomeric excess (>99%) by enzymatic kinetic resolution using the haloalcohol dehalogenase HheC. Yields were close to the theoretical maximum for all substrates employed. Furthermore, the applicability of this methodology on multigram scale has been established.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 5 2 شماره
صفحات -
تاریخ انتشار 2007